Aqueous Solubility of Poorly Water-Soluble Drug Ibuprofen in Micellar Media: Effect of Head Groups Charge
کد مقاله : 1155-PHYSCHEM20
فرزانه تیموری، مرتضی جباری *
دانشجو- دانشگاه دامغان
چکیده مقاله:
In this study, equilibrium solubility of ibuprofen (IBP) as a poorly water-soluble drug was determined in pure water and in aqueous micellar solutions consisting of anionic SDS, cationic CTAB and non-ionic Brij-35 surfactants with different concentrations and charged head groups. The solubility data show that, irrespective of the surfactant type, the solubility of IBP in the micellar media increased compared to water by increasing solution concentration. Moreover, the non-ionic surfactant Brij-35 in lower concentrations than ionic surfactants CTAB and SDS can solve the drug ibuprofen better. This behaviour is a consequence of the interactions between the drug and the micelles under study.
کلیدواژه ها:
Ibuprofen; Solubility; Micellar effect; Aqueous media.
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