Effect of choline chloride / malonic acid deep eutectic solvent on the acetaminophen Solubility at T = (288.15 to 318.15) K
کد مقاله : 1207-PHYSCHEM20
معصومه مختارپور *
چکیده مقاله:
Deep eutectic solvents (DESs) as a new class of green solvents have been used to overcome the poor solubility of drugs during the recent years. In this work, the effect of DES containing choline chloride as hydrogen bond acceptor and malonic acid as hydrogen bond donor has been studied on acetaminophen (ACP) solubility at temperature ranges (298.15 to 313.15) K. The results indicate that the solubility of ACP increase with increasing concentration of DES and at higher temperatures. The solubility data were correlated by the modified Apelblat, λh (Buchowski) and Yalkowsky models which Apelblat model is more consistent with experimental data.
کلیدواژه ها:
“Deep eutectic solvent; Solubility”; “Acetaminophen”; “Modified Apelblat”.
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