Preparation of spherical super magnetic iron oxide nanoparticles and its application as drug delivery systems
کد مقاله : 1271-PHYSCHEM20
محمد حسین احمدی ازغندی *
چکیده مقاله:
In this research, spherical superparamagnetic iron oxide nanoparticles with mean diameter of 6 -10 nm were prepared by a reduction–precipitation method. The surface of spherical superparamagnetic iron oxide nanoparticles SPION were coated with poly (methacrylic acid) (PMAA) and followed by loading with the anticancer drug DOX (doxorubicin). The drug loading efficiency was (14.64 ± 0.29). In vitro drug release studies were realized for 8 h at two different pH values. The drug release rate at acidic pH was much faster than that at natural pH. These results also indicate that DOX/PMAA nanoparticles have a favourable release property and drug release kinetics followed the Korsmeyer–Peppas model. The samples were characterized by XRD, SEM, TEM, FTIR, and UV-Vis.
کلیدواژه ها:
Release kinetic studies; magnetite drug targeting; functionalization; poly(methacrylic acid); anticancer drug.
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