Flouoresence study on the interaction between Nickel (II) Complex [Ni(bin)2OAC] and bovine serum albumin
کد مقاله : 1279-PHYSCHEM20
نویسندگان:
نسرین سهرابی *، 1محبوبه اسلامی مقدم، 2راضیه امراللهی کوپائی
1عضو علمی سازمان پژوهشهای علمی و صنعتی
2دانشجو
چکیده مقاله:
Abstract The interaction of Nickel (II) Complex [Ni(bin)2OAC] and bovine serum albumin (BSA) was studied by fluorescence spectroscopy at room temperatures. The results revealed that Nickel (II) Complex [Ni(bin)2OAC] caused the fluorescence quenching of BSA through a static quenching procedure. The binding constants (Kb‌ ), and the number of binding sites (n), were obtaind to be 1.11×106 ‌and 1.040 at 298K, respectively. The primary binding pattern between Nickel (II) Complex [Ni(bin)2OAC] and BSA was interpreted as hydrophobic interaction. in this study, it was decided that new water soluble compound of binicotinicacid ligand with formula [Ni(bin)2OAC],(bin= 2,2-bipyridine-3,3-dicarboxylic) will be designed and synthesized.
کلیدواژه ها:
Bovine serum albumin (BSA), Fluorescence spectra, Interaction, [Ni(bini)2 ](OAC)2
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